The nexus approach can enhance understanding of the interconnectedness of the food-water-energy sectors and strengthen coordination among them. But it requires a major shift in the decision-making process towards taking a holistic view and developing institutional mechanisms to coordinate the actions of diverse actors and strengthen complementarities and synergies among the three sectors. A framework is suggested for cross-sectoral coordination and managing the nexus challenges, with a view toward meeting the Sustainable Development Goals in South Asia.